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macs2---使用记录

macs2---使用记录

作者: shine_9457 | 来源:发表于2021-02-03 20:45 被阅读0次
    -- (base) [yangjy@GSCG01 dum]$ macs2 callpeak -c  Control.merge.rmdup.bam -t H2Aub1.merge.rmdup.bam -f BAM -B -g mm -n H2Aub1
    INFO  @ Wed, 03 Feb 2021 12:22:13:
    # Command line: callpeak -c Control.merge.rmdup.bam -t H2Aub1.merge.rmdup.bam -f BAM -B -g mm -n H2Aub1
    # ARGUMENTS LIST:
    # name = H2Aub1
    # format = BAM
    # ChIP-seq file = ['H2Aub1.merge.rmdup.bam']
    # control file = ['Control.merge.rmdup.bam']
    # effective genome size = 1.87e+09
    # band width = 300
    # model fold = [5, 50]
    # qvalue cutoff = 5.00e-02
    # The maximum gap between significant sites is assigned as the read length/tag size.
    # The minimum length of peaks is assigned as the predicted fragment length "d".
    # Larger dataset will be scaled towards smaller dataset.
    # Range for calculating regional lambda is: 1000 bps and 10000 bps
    # Broad region calling is off
    # Paired-End mode is off
    

    处理进程

    INFO  @ Wed, 03 Feb 2021 12:22:13: #1 read tag files...  
    INFO  @ Wed, 03 Feb 2021 12:22:13: #1 read treatment tags...    读取 实验组
    INFO  @ Wed, 03 Feb 2021 12:22:15:  1000000
    INFO  @ Wed, 03 Feb 2021 12:22:16:  2000000
    INFO  @ Wed, 03 Feb 2021 12:22:18:  3000000
    INFO  @ Wed, 03 Feb 2021 12:22:19:  4000000
    INFO  @ Wed, 03 Feb 2021 12:22:21:  5000000
    INFO  @ Wed, 03 Feb 2021 12:22:22:  6000000
    INFO  @ Wed, 03 Feb 2021 12:22:24:  7000000
    INFO  @ Wed, 03 Feb 2021 12:22:25:  8000000
    INFO  @ Wed, 03 Feb 2021 12:22:27:  9000000
    INFO  @ Wed, 03 Feb 2021 12:22:28:  10000000
    INFO  @ Wed, 03 Feb 2021 12:22:30:  11000000
    INFO  @ Wed, 03 Feb 2021 12:22:32:  12000000
    INFO  @ Wed, 03 Feb 2021 12:22:33:  13000000
    INFO  @ Wed, 03 Feb 2021 12:22:35:  14000000
    INFO  @ Wed, 03 Feb 2021 12:22:36:  15000000
    INFO  @ Wed, 03 Feb 2021 12:22:38:  16000000
    INFO  @ Wed, 03 Feb 2021 12:22:39:  17000000
    INFO  @ Wed, 03 Feb 2021 12:22:41: 17515747 reads have been read.
    
    INFO  @ Wed, 03 Feb 2021 12:22:41: #1.2 read input tags...   *读取 对照组
    INFO  @ Wed, 03 Feb 2021 12:22:42:  1000000
    INFO  @ Wed, 03 Feb 2021 12:22:44:  2000000
    INFO  @ Wed, 03 Feb 2021 12:22:45:  3000000
    INFO  @ Wed, 03 Feb 2021 12:22:47:  4000000
    INFO  @ Wed, 03 Feb 2021 12:22:48:  5000000
    INFO  @ Wed, 03 Feb 2021 12:22:50:  6000000
    INFO  @ Wed, 03 Feb 2021 12:22:51:  7000000
    INFO  @ Wed, 03 Feb 2021 12:22:52:  8000000
    INFO  @ Wed, 03 Feb 2021 12:22:54:  9000000
    INFO  @ Wed, 03 Feb 2021 12:22:55:  10000000
    INFO  @ Wed, 03 Feb 2021 12:22:57:  11000000
    INFO  @ Wed, 03 Feb 2021 12:22:58:  12000000
    INFO  @ Wed, 03 Feb 2021 12:23:01: 12331048 reads have been read.
    
    INFO  @ Wed, 03 Feb 2021 12:23:01: #1 tag size is determined as 49 bps   
    INFO  @ Wed, 03 Feb 2021 12:23:01: #1 tag size = 49.0
    INFO  @ Wed, 03 Feb 2021 12:23:01: #1  total tags in treatment: 17515747
    INFO  @ Wed, 03 Feb 2021 12:23:01: #1 user defined the maximum tags...
    INFO  @ Wed, 03 Feb 2021 12:23:01: #1 filter out redundant tags at the same location and the same strand by allowing at most 1 tag(s)
    INFO  @ Wed, 03 Feb 2021 12:23:01: #1  tags after filtering in treatment: 17515746
    INFO  @ Wed, 03 Feb 2021 12:23:01: #1  Redundant rate of treatment: 0.00
    INFO  @ Wed, 03 Feb 2021 12:23:01: #1  total tags in control: 12331048
    INFO  @ Wed, 03 Feb 2021 12:23:01: #1 user defined the maximum tags...
    INFO  @ Wed, 03 Feb 2021 12:23:01: #1 filter out redundant tags at the same location and the same strand by allowing at most 1 tag(s)
    INFO  @ Wed, 03 Feb 2021 12:23:01: #1  tags after filtering in control: 12331048
    INFO  @ Wed, 03 Feb 2021 12:23:01: #1  Redundant rate of control: 0.00
    INFO  @ Wed, 03 Feb 2021 12:23:01: #1 finished!   # 完成
    INFO  @ Wed, 03 Feb 2021 12:23:01: #2 Build Peak Model... # 建立模型
    INFO  @ Wed, 03 Feb 2021 12:23:01: #2 looking for paired plus/minus strand peaks...
    INFO  @ Wed, 03 Feb 2021 12:23:03: #2 number of paired peaks: 4584  # 
    INFO  @ Wed, 03 Feb 2021 12:23:03: start model_add_line...
    INFO  @ Wed, 03 Feb 2021 12:23:03: start X-correlation...
    INFO  @ Wed, 03 Feb 2021 12:23:03: end of X-cor
    INFO  @ Wed, 03 Feb 2021 12:23:03: #2 finished!
    INFO  @ Wed, 03 Feb 2021 12:23:03: #2 predicted fragment length is 83 bps
    INFO  @ Wed, 03 Feb 2021 12:23:03: #2 alternative fragment length(s) may be 83 bps
    INFO  @ Wed, 03 Feb 2021 12:23:03: #2.2 Generate R script for model : H2Aub1_model.r
    WARNING @ Wed, 03 Feb 2021 12:23:03: #2 Since the d (83) calculated from paired-peaks are smaller than 2*tag length, it may be influenced by unknown sequencing problem!
    WARNING @ Wed, 03 Feb 2021 12:23:03: #2 You may need to consider one of the other alternative d(s): 83
    WARNING @ Wed, 03 Feb 2021 12:23:03: #2 You can restart the process with --nomodel --extsize XXX with your choice or an arbitrary number. Nontheless, MACS will continute computing.
    INFO  @ Wed, 03 Feb 2021 12:23:03: #3 Call peaks...
    INFO  @ Wed, 03 Feb 2021 12:23:03: #3 Pre-compute pvalue-qvalue table...
    INFO  @ Wed, 03 Feb 2021 12:23:48: #3 In the peak calling step, the following will be performed simultaneously:
    INFO  @ Wed, 03 Feb 2021 12:23:48: #3   Write bedGraph files for treatment pileup (after scaling if necessary)... H2Aub1_treat_pileup.bdg
    INFO  @ Wed, 03 Feb 2021 12:23:48: #3   Write bedGraph files for control lambda (after scaling if necessary)... H2Aub1_control_lambda.bdg
    INFO  @ Wed, 03 Feb 2021 12:23:48: #3   Pileup will be based on sequencing depth in control.
    INFO  @ Wed, 03 Feb 2021 12:23:48: #3 Call peaks for each chromosome...
    INFO  @ Wed, 03 Feb 2021 12:24:34: #4 Write output xls file... H2Aub1_peaks.xls
    INFO  @ Wed, 03 Feb 2021 12:24:34: #4 Write peak in narrowPeak format file... H2Aub1_peaks.narrowPeak
    INFO  @ Wed, 03 Feb 2021 12:24:34: #4 Write summits bed file... H2Aub1_summits.bed
    INFO  @ Wed, 03 Feb 2021 12:24:34: Done!
    [1]+  Done                    macs2 callpeak -c Control.merge.rmdup.bam -t H2Aub1.merge.rmdup.bam -f BAM -B -g mm -n H2Aub1 2> H2Aub1.macs2.log
    

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