To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints.
下载链接： https://api.gdc.cancer.gov/data/1b5f413e-a8d1-4d10-92eb-7c4ae739ed81
关于生存分析该选择哪个时间点
这不是一个选择题，既然人家TCGA组织整理了 four major clinical outcome endpoints. 那么这些时间点都可以，不同的选择得到的结果的生物学解释不一样。
疾病特异性生存期 DSS: disease-specific survival event, 1 for patient whose vital_status was Dead and tumor_status was WITH TUMOR. If a patient died from the disease shown in field of cause_of_death, the status of DSS would be 1 for the patient. 0 for patient whose vital_status was Alive or whose vital_status was Dead and tumor_status was TUMOR FREE. This is not a 100% accurate definition but is the best we could do with this dataset. Technically a patient could be with tumor but died of a car accident and therefore incorrectly considered as an event.
DSS.time: disease-specific survival time in days, last_contact_days_to or death_days_to, whichever is larger.
无病间隔期 DFI: disease-free interval event, 1 for patient having new tumor event whether it is a local recurrence, distant metastasis, new primary tumor of the cancer, including cases with a new tumor event whose type is N/A. Disease free was defined by: first, treatment_outcome_first_course is "Complete Remission/Response"; if the tumor type doesn't have "treatment_outcome_first_course" then disease-free was defined by the value "R0" in the field of "residual_tumor"; otherwise, disease-free was defined by the value "negative" in the field of "margin_status". If the tumor type did not have any of these fields, then its DFI was NA.
DFI.time: disease-free interval time in days, new_tumor_event_dx_days_to for events, or for censored cases, either last_contact_days_to or death_days_to, whichever is applicable.
无进展间隔期 PFI: progression-free interval event, 1 for patient having new tumor event whether it was a progression of disease, local recurrence, distant metastasis, new primary tumors all sites , or died with the cancer without new tumor event, including cases with a new tumor event whose type is N/A.
PFI.time: progression-free interval time in days, for events, either new_tumor_event_dx_days_to or death_days_to, whichever is applicable; or for censored cases, either last_contact_days_to or death_days_to, whichever is applicable.
文章引自 《TCGA数据库临床资料官方大全》——生信技能书Jimmy大神总结
https://cloud.tencent.com/developer/article/1446575
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