problem/ question/ matter
(1)problem多指“习题，问题”，通常也指要解决或决定的问题，尤其指比较困难的问题、社会问题。
ZhangXiaobao is thinking about a maths problem.张小宝正在想一道数学难题。
You are getting fatter. It’s a problem.你长胖了，这可是个问题。
(2)question 常指由于对某事感到疑惑不解而提出需要解答的问题，
常与ask和answer连用。
May I ask a question?我可以问个问题吗？
(3)matter意为“事情”、“问题”，常指遇到意外的麻烦或令人烦恼的“问题”
What’s the matter with you?你怎么啦？
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本文标题：What is the matter with you
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