差异的甲基化
差异的甲基化位点位于基因的prometer区域，我们才去保留，主要包括（TSS200和TSS1500）
注释文件来自ChAMP工具包，data一下即可
一般的差异定义标准为
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参考文献：Immune Signature-Based Subtypes of Cervical Squamous Cell Carcinoma Tightly Associated with
Human Papillomavirus Type 16 Expression, Molecular Features, and Clinical Outcome
差异标准提高：
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参考文献：Epigenetic age acceleration of cervical squamous cell carcinoma converged to human papillomavirus 16/18 expression, immunoactivation, and favourable prognosis
promoter regions 默认（TSS200和TSS1500）
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参考文献：The signature of HBV-related liver disease in peripheral blood mononuclear cell DNA methylation
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