Synthesis and Antitumor Activity

Three novel nitroxyl labeled derivatives of podophyllotoxin 5-7 have been synthesized andevaluated for their antitumor activity against mouse leukemia L1210 cell in vitro. Compounds 5exhibited superior activity to clinically used etoposide (VP-16, 2) in its inhibition of this cell line.rn Podoph......

【作者名称】: Shaoyuan Chen,Yongping Yu,Yaozu Chen

【作者单位】: College of Life science,Zhejiang University,Hangzhou 310027,P.R.China;Department of Chemistry,Zhejiang University,Hangzhou 310027,E R.China

【关 键 词】: 抗肿瘤活性, 自旋标记, 鬼臼毒素, 衍生物, 白血病, 动物模型

【原文地址】: https://www.zhangqiaokeyan.com/academic-conference-cn_meeting-28435_thesis/020222013072.html

【会议名称】: 首届长三角科技论坛：长三角生物医药发展论坛论文集

【会议地点】: 杭州

【会议组织】: 中国药学会;中国生物工程学会;浙江省药学会;上海市药学会

【会议时间】: 2004