MultiDex Support库引发的NoClassDefFo

今天在低端机器上面遇到一个奇怪的启动闪退：

Process: com.flyme.videoclips
Flags: 0xa83e46
Package: com.flyme.videoclips v2007000 (2.7.0)
Build: Meizu/meizu_m3note/m3:5.1/LMY47I/1532423771:user/release-keys

java.lang.NoClassDefFoundError: Failed resolution of: Landroid/support/multidex/MultiDex;
    at com.flyme.videoclips.VideoClipsApplication.attachBaseContext(VideoClipsApplication.java:71)
    at android.app.Application.attach(Application.java:197)
    at android.app.Instrumentation.newApplication(Instrumentation.java:1004)
    at android.app.Instrumentation.newApplication(Instrumentation.java:988)
    at android.app.LoadedApk.makeApplication(LoadedApk.java:607)
    at android.app.ActivityThread.handleBindApplication(ActivityThread.java:5111)
    at android.app.ActivityThread.access$1600(ActivityThread.java:187)
    at android.app.ActivityThread$H.handleMessage(ActivityThread.java:1659)
    at android.os.Handler.dispatchMessage(Handler.java:111)
    at android.os.Looper.loop(Looper.java:194)
    at android.app.ActivityThread.main(ActivityThread.java:5914)
    at java.lang.reflect.Method.invoke(Native Method)
    at java.lang.reflect.Method.invoke(Method.java:372)
    at com.android.internal.os.ZygoteInit$MethodAndArgsCaller.run(ZygoteInit.java:1127)
    at com.android.internal.os.ZygoteInit.main(ZygoteInit.java:893)
Caused by: java.lang.ClassNotFoundException: Didn't find class "android.support.multidex.MultiDex" on path: DexPathList[[zip file "/data/app/com.flyme.videoclips-2/base.apk"],nativeLibraryDirectories=[/data/app/com.flyme.videoclips-2/lib/arm, /vendor/lib, /system/lib]]
    at dalvik.system.BaseDexClassLoader.findClass(BaseDexClassLoader.java:56)
    at java.lang.ClassLoader.loadClass(ClassLoader.java:511)
    at java.lang.ClassLoader.loadClass(ClassLoader.java:469)
    ... 15 more
    Suppressed: java.lang.ClassNotFoundException: android.support.multidex.MultiDex
        at java.lang.Class.classForName(Native Method)
        at java.lang.BootClassLoader.findClass(ClassLoader.java:781)
        at java.lang.BootClassLoader.loadClass(ClassLoader.java:841)
        at java.lang.ClassLoader.loadClass(ClassLoader.java:504)
        ... 16 more
    Caused by: java.lang.NoClassDefFoundError: Class not found using the boot class loader; no stack available

研究了一下，以前魅族的老机型会做dex预优化，Debug编译出来的包会有比较多的dex文件，Release编译出来的包只有3个dex文件。老机型在安装Debug包后会闪退（注意Android Studio默认直接编译运行的也是Debug包），对比图如下：