胆固醇合成调节基因

SREBF1：固醇调节元件结合转录因子1
This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis.
该基因编码一个碱性螺旋-环-螺旋-亮氨酸拉链（bHLH-Zip）转录因子，与LDLR基因启动子和固醇生物合成的其他基因启动子中的基序-固醇调节元件1（SRE1）结合。
The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum.
编码的蛋白质合成前体后，该前体最初附着于核膜和内质网。
Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols.
切割后，成熟蛋白易位至细胞核并激活转录。这种切割被固醇抑制。
SREBF2：固醇调节元件结合转录因子2
This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes.
该基因编码一种广泛表达的转录因子的成员，该转录因子通过调节固醇调节基因的转录来控制胆固醇稳态。
The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif.
编码的蛋白质包含一个基本的螺旋环-螺旋-亮氨酸拉链(bHLH-Zip)域，并结合甾醇调控元件1基序。
SCAP：
This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains.
该基因编码的蛋白质具有一个甾醇感应结构域(SSD)和七个WD结构域。
In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis.
在胆固醇存在的情况下，与甾醇调节元件结合蛋白(SREBPs)结合，并介导其从ER到高尔基体的转运。然后SREBPs被蛋白切割并调节甾醇的生物合成。