https://genome.cshlp.org/content/20/10/1313
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The most probable fate of a du- plicate gene copy is pseudogenization (Ohno 1972) and that hence the majority of duplicate gene copies are eventually lost from the genome
https://www.science.org/doi/10.1126/science.1178487
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Gene duplication may occur through unequal crossing-over of duplicated chromosomes harboring the gene during meiotic cell divisions in the germ line. This recombination is mediated by, for example, homologous retrotransposable elements that fl ank the gene.
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