如果不使用模拟器，直接：

lipo 文件夹/可执行文件 -remove x86_64 -output 文件夹/可执行文件

在不删除 framework 中的 x86_64 和 i386 指令集的情况下,
删除 archive 包中 framework 的 x86_64 和 i386, 这样依然可以支持模拟器.

framework 去除不支持的指令集
在 Build Phases -> Embed Frameworks 下面添加一个新的 Script, 内容如下:

两段 Script 任选其一

Script 1

echo "Target architectures: $ARCHS"

APP_PATH="${TARGET_BUILD_DIR}/${WRAPPER_NAME}"

find "$APP_PATH" -name '*.framework' -type d | while read -r FRAMEWORK
do
FRAMEWORK_EXECUTABLE_NAME=$(defaults read "$FRAMEWORK/Info.plist" CFBundleExecutable)
FRAMEWORK_EXECUTABLE_PATH="$FRAMEWORK/$FRAMEWORK_EXECUTABLE_NAME"
echo "Executable is $FRAMEWORK_EXECUTABLE_PATH"
echo $(lipo -info "$FRAMEWORK_EXECUTABLE_PATH")

FRAMEWORK_TMP_PATH="$FRAMEWORK_EXECUTABLE_PATH-tmp"

# remove simulator's archs if location is not simulator's directory
case "${TARGET_BUILD_DIR}" in
*"iphonesimulator")
    echo "No need to remove archs"
    ;;
*)
    if $(lipo "$FRAMEWORK_EXECUTABLE_PATH" -verify_arch "i386") ; then
    lipo -output "$FRAMEWORK_TMP_PATH" -remove "i386" "$FRAMEWORK_EXECUTABLE_PATH"
    echo "i386 architecture removed"
    rm "$FRAMEWORK_EXECUTABLE_PATH"
    mv "$FRAMEWORK_TMP_PATH" "$FRAMEWORK_EXECUTABLE_PATH"
    fi
    if $(lipo "$FRAMEWORK_EXECUTABLE_PATH" -verify_arch "x86_64") ; then
    lipo -output "$FRAMEWORK_TMP_PATH" -remove "x86_64" "$FRAMEWORK_EXECUTABLE_PATH"
    echo "x86_64 architecture removed"
    rm "$FRAMEWORK_EXECUTABLE_PATH"
    mv "$FRAMEWORK_TMP_PATH" "$FRAMEWORK_EXECUTABLE_PATH"
    fi
    ;;
esac

echo "Completed for executable $FRAMEWORK_EXECUTABLE_PATH"
echo $(lipo -info "$FRAMEWORK_EXECUTABLE_PATH")

done

Script 2

如果有引用 framework 但没使用也会删除掉 removes unused architectures.

# This script loops through the frameworks embedded in the application 
# and removes unused architectures.

find "${TARGET_BUILD_DIR}/${WRAPPER_NAME}" -name '*.framework' -type d | while read -r FRAMEWORK; do
    FRAMEWORK_EXECUTABLE_NAME=$(defaults read "$FRAMEWORK/Info.plist" CFBundleExecutable)
    FRAMEWORK_EXECUTABLE_PATH="$FRAMEWORK/$FRAMEWORK_EXECUTABLE_NAME"
    for arch in $(lipo -archs $FRAMEWORK_EXECUTABLE_PATH); do
        if ! printf '%s\n' ${ARCHS[@]} | egrep -q "^$arch$"; then
            lipo -remove $arch "$FRAMEWORK_EXECUTABLE_PATH" -o "$FRAMEWORK_EXECUTABLE_PATH" 
        fi
    done
done

Reference: https://stackoverflow.com/questions/30547283/submit-to-app-store-issues-unsupported-architecture-x86

Reference: https://stackoverflow.com/questions/42641806/check-and-remove-unsupported-architecture-x86-64-i386-in-ipa-archive