The Rudolf Virchow Center / Research Center for Experimental Biomedicine of the University of Würzburg
offers at the earliest possible date a position as
PhD student (f/m/d, MSc in physics, biophysics or biochemistry)
for research in the field of
Superresolution Imaging
In this interdisciplinary approach we will develop an analysis platform based on Expansion Microscopy and single molecule localization modalities on blood platelets. We postulate that dimerization of the platelet receptors in diseased conditions triggers changes in the membrane organization and distribution of the receptor that modulate platelet adhesiveness independently of classic signaling pathways. Physical expansion of the small platelet by a hydrogel approach is one major prerequisite to map receptor clustering/distribution and interaction with other receptors and intracellular proteins over a large sample thickness.
The project involves the development of tailored expansion and advanced image data analysis tools. The overall goal is to provide a multi-color receptor mapping and co-localization study with single molecule resolution and minimized bias. The project particularly requires enthusiasm for biomolecular sciences, high-resolution microscopy, and computational image analysis.
The position is initially funded for a period of one year and will be extended in the case of a positive evaluation. The salary for this temporary position is commensurate with training and experience according to Collective Agreement for the Public Service of German Federal States TV-L.
Applications including cover letter, detailed CV, copies of certificates, and contact information of two referees, should be sent as a single pdf file (no more than 10 MB) via email to katrin.heinze@virchow.uni-wuerzburg.de until 24th of May 201
Desired skills and experience
We are interested in a PhD candidate with a strong background in physics, preferably biophysics, or engineering or an equivalent level of professional qualification and experience. Ideally, the candidate has experience in fluorescence imaging / spectroscopy and quantitative data analysis. Experience in superresolution and single-molecule imaging is desired, however not a prerequisite.
About the employer
The successful candidate will work at the Rudolf Virchow Center of the University of Würzburg funded by the TRR-CRC166 (ReceptorLight). In an international and multi-disciplinary environment with strong expertise in biophysical research we provide state-of-the-art technologies, and the opportunity to enroll in the Graduate School of Life Sciences ─ an international graduate program. Female scientists are particularly encouraged to apply. Disabled applicants will be preferentially considered in case of equivalent qualification.
Areas of Research
Biochemistry
Biomedical Engineering
Cell Biophysics
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维尔茨堡大学Rudolf Virchow中心/实验生物医学研究中心
提供尽可能早的日期
博士生（f / m / d，物理，生物物理或生物化学硕士）
用于研究领域
超分辨率成像
在这种跨学科方法中，我们将开发基于扩增显微镜和血小板上单分子定位模式的分析平台。
我们假设血小板受体在疾病状态下的二聚化触发了膜组织和受体分布的变化，该受体调节血小板粘附性而与经典信号传导途径无关。
通过水凝胶方法对小血小板的物理扩张是绘制受体聚集/分布以及在大样品厚度上与其他受体和细胞内蛋白质相互作用的一个主要先决条件。
该项目涉及开发定制的扩展和先进的图像数据分析工具。总体目标是提供具有单分子分辨率和最小偏差的多色受体作图和共定位研究。
该项目特别需要对生物分子科学，高分辨率显微镜和计算图像分析的热情。
该职位最初的资助期限为一年，并在积极评估的情况下延长。根据德国联邦国家公共服务集体协议TV-L，这个临时职位的薪水与培训和经验相称。
申请表包括求职信，详细简历，证书复印件和两名推荐人的联系信息，应通过电子邮件发送至katrin.heinze@virchow.uni-wuerzburg.de，直至24日为单个pdf文件（不超过10 MB）。
期望的技能和经验
我们感兴趣的是具有强大物理背景，优选生物物理学或工程学或同等水平的专业资格和经验的博士候选人。理想情况下，候选人具有荧光成像/光谱学和定量数据分析的经验。需要超分辨和单分子成像的经验，但不是先决条件。
关于雇主
这位成功的候选人将在TRR-CRC166（ReceptorLight）资助的维尔茨堡大学Rudolf Virchow中心工作。在具有丰富生物物理研究专业知识的国际和多学科环境中，我们提供最先进的技术，并有机会进入生命科学研究生院 - 一个国际研究生课程。
特别鼓励女科学家申请。如果具有同等资格，将优先考虑残疾申请人。
研究领域
生物化学
生物医学工程
细胞生物物理学
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