2019-03-25 动态功能连接和精神障碍

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Hum Brain Mapp. 2017 May;38(5):2683-2708. doi: 10.1002/hbm.23553. Epub 2017 Mar 10.

Identifying dynamic functional connectivity biomarkers using GIG-ICA: Application to schizophrenia, schizoaffective disorder, and psychotic bipolar disorder.

Du Y1,2, Pearlson GD3,4,5, Lin D1, Sui J1,6, Chen J1, Salman M1,7, Tamminga CA8, Ivleva EI8, Sweeney JA8,9, Keshavan MS10, Clementz BA11, Bustillo J12, Calhoun VD1,3,7,12.

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Functional magnetic resonance imaging (fMRI) studies have shown altered brain dynamic functional connectivity (DFC) in mental disorders. Here, we aim to explore DFC across a spectrum of symptomatically-related disorders including bipolar disorder with psychosis (BPP), schizoaffective disorder (SAD), and schizophrenia (SZ). We introduce a group information guided independent component analysis procedure to estimate both group-level and subject-specific connectivity states from DFC. Using resting-state fMRI data of 238 healthy controls (HCs), 140 BPP, 132 SAD, and 113 SZ patients, we identified measures differentiating groups from the whole-brain DFC and traditional static functional connectivity (SFC), separately. Results show that DFC provided more informative measures than SFC. Diagnosis-related connectivity states were evident using DFC analysis. For the dominant state consistent across groups, we found 22 instances of hypoconnectivity (with decreasing trends from HC to BPP to SAD to SZ) mainly involving post-central, frontal, and cerebellar cortices as well as 34 examples of hyperconnectivity (with increasing trends HC through SZ) primarily involving thalamus and temporal cortices. Hypoconnectivities/hyperconnectivities also showed negative/positive correlations, respectively, with clinical symptom scores. Specifically, hypoconnectivities linking postcentral and frontal gyri were significantly negatively correlated with the PANSS positive/negative scores. For frontal connectivities, BPP resembled HC while SAD and SZ were more similar. Three connectivities involving the left cerebellar crus differentiated SZ from other groups and one connection linking frontal and fusiform cortices showed a SAD-unique change. In summary, our method is promising for assessing DFC and may yield imaging biomarkers for quantifying the dimension of psychosis. Hum Brain Mapp 38:2683-2708, 2017.

© 2017 Wiley Periodicals, Inc.

Neuroimage. 2018 Oct 15;180(Pt B):515-525. doi: 10.1016/j.neuroimage.2017.09.036. Epub 2017 Sep 21.

The behavioral and cognitive relevance of time-varying, dynamic changes in functional connectivity.

Cohen JR1.

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Recent advances in neuroimaging methods and analysis have led to an expanding body of research that investigates how large-scale brain network organization dynamically adapts to changes in one's environment, including both internal state changes and external stimulation. It is now possible to detect changes in functional connectivity that occur on the order of seconds, both during an unconstrained resting state and during the performance of constrained cognitive tasks. It is thought that these dynamic, time-varying changes in functional connectivity, often referred to as dynamic functional connectivity (dFC), include features that are relevant to behavior and cognition. This review summarizes four aspects of the nascent literature directly testing that assumption: 1) how changes in functional network organization on the order of task blocks relate to differences in task demands and to cognitive ability; 2) how differences in dFC variability between different contexts relate to cognitive demands and behavioral performance; 3) how ongoing fluctuations in dFC impact perception and attention; and 4) how different patterns of dFC correspond to individual differences in cognition. The review ends by discussing promising directions for future research in this field. First, it comments on how dFC analyses can help to elucidate the mechanisms of healthy cognition. Next, it describes how dFC processes may be disrupted in disease, and how probing such dysfunction can increase understanding of neural etiology, as well as behavioral and cognitive impairments, observed in psychiatric and neurologic populations. Last, it considers the potential for computational models to uncover neuronal mechanisms of dFC, and how both healthy cognition and disease emerge from network dynamics.