Delafloxacin葡甲胺是一种氟喹诺酮类抗生素

　　Delafloxacin葡甲胺是一种氟喹诺酮类抗生素。

Delafloxacin分子图

　　Delafloxacin meglumine Chemical Structure

　　CAS No. : 352458-37-8

　　分子量：635.97

　　分子式：C₂₅H₂₉ClF₃N₅O₉

　　CAS No.：352458-37-8

　　纯度： 98.08%

　　描述：Delafloxacin葡甲胺是一种氟喹诺酮类抗生素。IC50值：对于左氧氟沙星耐药的肺炎链球菌菌株，MIC为0.0078至0.125微克/毫升[1]目标：抗菌ABT-492对喹诺酮敏感和抗性革兰氏阳性菌更有效，其活性与环丙沙星针对肠杆菌科的某些成员，具有与喹诺酮敏感，非发酵，革兰氏阴性生物相当的活性。体外：ABT-492对MICs（以微克/毫升计）测试的所有326个需氧和厌氧性胃窦穿刺窦分离物均表现出优异的体外活性，其中90％的受试分离株被抑制如下：流感嗜血杆菌，0.001;粘膜炎莫拉氏菌，0.008;和肺炎链球菌，0.015[2]。 ABT-492与沙罗沙星对抗沙眼衣原体一样活跃，表明细胞内渗透性和抗菌活性良好[3]。

　　相关文献：

　　[1]. Gunderson SM, Hayes RA, Quinn JP, In vitro pharmacodynamic activitiesof ABT-492, a novel quinolone, compared to those of levofloxacin againstStreptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.Antimicrob Agents Chemother. 2004 Jan;48(1):203-8.

　　[2]. Goldstein EJ, Citron DM, Merriam CV, In vitro activities of ABT-492, anew fluoroquinolone, against 155 aerobic and 171 anaerobic pathogens isolatedfrom antral sinus puncture specimens from patients with sinusitis. AntimicrobAgents Chemother. 2003 Sep;47(9):3008-11.

　　[3]. Nilius AM, Shen LL, Hensey-Rudloff D, In vitro antibacterial potencyand spectrum of ABT-492, a new fluoroquinolone. Antimicrob Agents Chemother.2003 Oct;47(10):3260-9.