Differential alternative splicing regulation among hepatocellular carcinoma with different risk factors
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Fig 3
分析完可变剪接事件后，作者选取其中29个差异显著的基因， 在这29个基因中，有3个可以再PPI中找到（上图红色虚线），case1 2 3是分别分析3个基因的可变剪接事件。
We selected 29 unique genes with stronger differential values (ΔPSI> 0.1) between the groups, and of those 29, three genes (i.e., HLA-A, HLA-C, and IP6K2) were found in the PPI network (Fig. 3a; red circle). These genes commonly showed strong differential AS event (ΔPSI>0.1) and were specifically implicated in the immune system pathway as HBV-specific AS genes (Fig. 3b). For these genes, case studies were performed to evaluate the functional or clinical impact of AS event, HLA-A, HLA-C, and IP6K2.
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