CZC24832

"目录号: HY-15294

PI3K/Akt/mTOR-

CZC24832是PI3Kγ选择性抑制剂，在PI3Kγ依赖的fMLP诱导的中性粒细胞迁移实验中IC50为1.0 μM，且对其它多种蛋白的脱靶效应极有限。

PI3K

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生物活性

Description

CZC24832 is a selective inhibitor of PI 3-kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay); exhibits limited off-target effects in kinome profiling of 154 identified lipid and protein kinases and 922 other proteins.IC50 value: 1.0 uMTarget: PI 3Kγ

References

[1].Bell K, et al.  SAR studies around a series of triazolopyridines as potent and selective PI3Kγ inhibitors.  oorg Med Chem Lett. 2012 Aug 15;22(16):5257-5263.

[2].Bergamini G, et al.  A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation.  Nat Chem Biol. 2012 Apr 29;8(6):576-582.