免疫知识点

Inflammatory profiles and checkpoint landsscape(PMID: 32201203)

seven metagenes

HCK,IgG,Interferon,LCK,MHC-I,MHC-II,STAT1

seven metagenes

B7-CD28家族

PDL1,PDL2,ICOSLG,B7-H3,HHLA2,CTLA4,ICOS,PD-1,TMIGD2

TNF超家族

BTLA,LIGHT,CD40,OX40,4-1BB,CD27,CD40LG,OX40L,4-1BB-L,CD77,AITR

其他免疫检查点

TIM3,IDO1,LAG3,FGL1,CD39,CD73,SIGLEC15,VSIR,NCR3

免疫检查点

CIBERSORT

包含LM22（22种免疫细胞的表达矩阵）

LM22

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tumors associated infiltrating lymphocytes (TILs)

肿瘤相关浸润淋巴细胞，包含24种类型，具体细胞标志物参见下面文献附表2：
YTHDF1 Is a Potential Pan-Cancer Biomarker for Prognosis and Immunotherapy

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免疫检查点

PMID: 33879726
免疫检查点(PD1, PDL1, LAG3, HAVCR2, BTLA, CTLA4)

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免疫刺激和抑制因子

33 immunostimulators (CD27, VSIR, CD28, CD40, CD40LG, CD48, CD80, CD86, CXCL12, CXCR4, ENTPD1, HHLA2, ICOS, ICOSLG, IL2RA, IL6, IL6R, KLRK1, LTA, PVR, TMEM173, TMIGD2, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF25, TNFRSF8, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, and TNFSF9) and 17 immunoinhibitors (ADORA2A, BTLA, CD160, CD244, CD274, CD96, CSF1R, CTLA4, HAVCR2, IL10, KDR, LGALS9, PDCD1, PDCD1LG2, NECTIN2, TGFB1, and TIGIT)

PMID: 33747955