【文献速递】-SARS-CoV-2 entry factors

We investigated SARS-CoV-2 potential tropism by survey- ing expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.

我们通过调查来自健康人体供体多个组织的病毒进入相关基因的单细胞rna测序数据，研究SARS-CoV-2的潜在向性。我们在特定的呼吸道、角膜和肠道上皮细胞中共同检测到这些转录本，这可能解释了SARS-CoV-2的高效传播。这些基因在鼻上皮细胞中与参与先天免疫的基因共表达，突出了细胞在初始病毒感染、传播和清除中的潜在作用。该研究为进一步查询COVID-19患者的宝贵临床样本提供了有用的资源，我们在www.covid19cellatlas.org以全面、开放和用户友好的方式提供数据。