数据来源

Sanchez-Vega F, Mina M, Armenia J, Chatila WK, Luna A, La KC, et al. Oncogenic Signaling Pathways in The Cancer Genome Atlas. Cell. 2018; 173: 321-37 e10

癌症相关的十大pathway基因列表

pathway gene
RTK RAS pathway EGFR
RTK RAS pathway ERBB2
RTK RAS pathway ERBB3
RTK RAS pathway ERBB4
RTK RAS pathway MET
RTK RAS pathway PDGFRA
RTK RAS pathway FGFR1
RTK RAS pathway FGFR2
RTK RAS pathway FGFR3
RTK RAS pathway FGFR4
RTK RAS pathway KIT
RTK RAS pathway IGF1R
RTK RAS pathway RET
RTK RAS pathway ROS1
RTK RAS pathway ALK
RTK RAS pathway FLT3
RTK RAS pathway NTRK1
RTK RAS pathway NTRK2
RTK RAS pathway NTRK3
RTK RAS pathway JAK2
RTK RAS pathway CBL
RTK RAS pathway ERRFI1
RTK RAS pathway ABL1
RTK RAS pathway SOS1
RTK RAS pathway NF1
RTK RAS pathway RASA1
RTK RAS pathway PTPN11
RTK RAS pathway KRAS
RTK RAS pathway HRAS
RTK RAS pathway NRAS
RTK RAS pathway RIT1
RTK RAS pathway ARAF
RTK RAS pathway BRAF
RTK RAS pathway RAF1
RTK RAS pathway RAC1
RTK RAS pathway MAPK1
RTK RAS pathway MAP2K1
RTK RAS pathway MAP2K2
Nrf2 pathway KEAP1
Nrf2 pathway CUL3
Nrf2 pathway NFE2L2
p53 pathway MDM2
p53 pathway MDM4
p53 pathway TP53
p53 pathway ATM
p53 pathway CHEK2
p53 pathway RPS6KA3
PI3K pathway PTEN
PI3K pathway INPP4B
PI3K pathway PIK3CA
PI3K pathway PIK3CB
PI3K pathway PIK3R2
PI3K pathway PIK3R1
PI3K pathway PIK3R3
PI3K pathway AKT1
PI3K pathway AKT2
PI3K pathway AKT3
PI3K pathway PPP2R1A
PI3K pathway STK11
PI3K pathway TSC1
PI3K pathway TSC2
PI3K pathway RHEB
PI3K pathway RICTOR
PI3K pathway MTOR
PI3K pathway RPTOR
Cell cycle pathway CDKN2A
Cell cycle pathway CDKN2B
Cell cycle pathway CDKN2C
Cell cycle pathway CDKN1A
Cell cycle pathway CDKN1B
Cell cycle pathway CCNE1
Cell cycle pathway RB1
Cell cycle pathway CCND1
Cell cycle pathway CCND2
Cell cycle pathway CCND3
Cell cycle pathway CDK2
Cell cycle pathway CDK4
Cell cycle pathway CDK6
Cell cycle pathway E2F1
Cell cycle pathway E2F3
Wnt pathway WIF1
Wnt pathway SFRP1
Wnt pathway SFRP2
Wnt pathway SFRP3
Wnt pathway SFRP4
Wnt pathway SFRP5
Wnt pathway RNF43
Wnt pathway ZNRF3
Wnt pathway LRP5
Wnt pathway LRP6
Wnt pathway DKK1
Wnt pathway DKK2
Wnt pathway DKK3
Wnt pathway DKK4
Wnt pathway AXIN1
Wnt pathway AXIN2
Wnt pathway AMER1
Wnt pathway CTNNB1
Wnt pathway GSK3B
Wnt pathway APC
Wnt pathway TCF7
Wnt pathway TCF7L1
Wnt pathway TCF7L2
Wnt pathway TLE1
Wnt pathway TLE2
Wnt pathway TLE3
Wnt pathway TLE4
Myc pathway MYC
Myc pathway MYCN
Myc pathway MAX
Myc pathway MGA
Myc pathway MXI1
Myc pathway MNT
Myc pathway MLX
TGFbeta pathway TGFBR1
TGFbeta pathway TGFBR2
TGFbeta pathway ACVR2A
TGFbeta pathway ACVR1B
TGFbeta pathway SMAD2
TGFbeta pathway SMAD3
TGFbeta pathway SMAD4
Hippo pathway DCHS1
Hippo pathway DCHS2
Hippo pathway FAT1
Hippo pathway FAT2
Hippo pathway FAT3
Hippo pathway FAT4
Hippo pathway TAOK1
Hippo pathway TAOK2
Hippo pathway TAOK3
Hippo pathway NF2
Hippo pathway SAV1
Hippo pathway STK3
Hippo pathway STK4
Hippo pathway WWC1
Hippo pathway LATS1
Hippo pathway LATS2
Hippo pathway MOB1A
Hippo pathway MOB1B
Hippo pathway CRB1
Hippo pathway CRB2
Hippo pathway YAP1
Hippo pathway PTPN14
Hippo pathway CSNK1E
Hippo pathway CSNK1D
Hippo pathway TEAD2
Notch pathway NOV
Notch pathway CNTN6
Notch pathway JAG2
Notch pathway ARRDC1
Notch pathway FBXW7
Notch pathway CUL1
Notch pathway NOTCH1
Notch pathway NOTCH2
Notch pathway NOTCH3
Notch pathway NOTCH4
Notch pathway DNER
Notch pathway PSEN2
Notch pathway MAML3
Notch pathway KAT2B
Notch pathway CREBBP
Notch pathway EP300
Notch pathway NCOR1
Notch pathway NCOR2
Notch pathway SPEN
Notch pathway KDM5A
Notch pathway HES-X
Notch pathway HEY-X