Hesperidin

"目录号: HY-15337

Autophagy-

Hesperidin (HP)是一个生物类黄酮，具有生物和药理属性是一种有效的抗氧化,抗炎,抗癌,与降脂降压代理活动。

Autophagy

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生物活性

Description

Hesperidin (HP) is a bioflavonoid that plays a role in plant defense and is abundant in citrus species, such as grapefruit, lemon and orange. Hesperidin is used effectively as a supplemental agent in complementary therapy protocols, since it possesses biological and pharmacological properties as an effective antioxidant, anti-inflammatory, anti-carcinogenic, and anti-hypertensive agent with lipid-lowering activity[1]IC50: hesperidin (IC50=116.68μmo/L))[4]in vitro:  hesperidin and linarin are two of the main constituent of Valeriana's extract exhibiting a high affinity to KATP channel, which are related to the control of Ca++ concentration and release of GABA in synaptic nerve terminal, mainly on cells of SN[2]in vivo: Hesperidin was dissolved in 1% carboxymethyl cellulose (CMC) and administered orally at a dose of 50 mg/kg for 10 consecutive days. In the control group, rats were treated with the corn oil and 1% CMC vehicle.[1]

Clinical Trial

NCT01881204

Purdue University-Nestec Ltd.

Osteoporosis, Postmenopausal

April 2011

NCT00914251

University of Rome Tor Vergata

Endothelial Dysfunction-Metabolic Syndrome

November 2008

Phase 2

NCT01773486

University of Maryland

Obesity-Insulin Resistance

June 2015

Phase 2

NCT00545116

Nestlé-National University of Malaysia

Osteopenia-Osteoporosis

October 2007

Phase 2

NCT02610491

Maastricht University Medical Center

Metabolic Syndrome-Obesity

February 2015

Phase 2

NCT02927483

SunWave Pharma-Opera Contract Research Organization SRL

Chronic Venous Insufficiency

November 2016

Phase 3

NCT00330096

Nestlé-Institut National de la Recherche Agronomique-Centre de Recherche en Nutrition Humaine. Clermont-Ferrand, France

Osteoporosis, Osteopenia

March 2006

Phase 3

NCT01477281

Laboratório Teuto Brasileiro S/A

Chronic Venous Insufficiency-Disease

February 2012

Phase 3

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References

[1].Asli Cetin, Ali Otlu et al. Protective effect of hesperidin on oxidative and histological liver damage following carbon tetrachloride administration in Wistar rats. Arch Med Sci, 2016 Jun 1, 12(3): 486-493.

[2].Gesivaldo Santos,  Bruno Andrade et al. SUR1 Receptor Interaction with Hesperidin and Linarin Predicts Possible Mechanisms of Action of Valeriana officinalis in Parkinson. Front Aging Neurosci, 2016,  8: 97.

[3].Jin Zhang, Jing Gao et al. Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest. BMC Cancer, 2015, 15: 682.

[4].Cetin A,  Otlu A, ea al. Protective effect of hesperidin on oxidative and histological liver damage following carbon tetrachlorideadministration in Wistar rats. Arch Med Sci, 2016 Jun 1, 12(3):486-93.