SRT 2104

"目录号: HY-15262

Cell Cycle/DNA DamageEpigenetics-

SRT 2104是小分子Sirtuin 1激活剂。

Sirtuin

相关产品

EX-527-SRT 1720 Hydrochloride-Quercetin-Sirtinol-Tenovin 6 Hydrochloride-Inauhzin-Tenovin-1-AK-7-Sirtuin modulator 1-Thiomyristoyl-AK-1-Ginkgolide C-Salermide-3-TYP-AGK2-

生物活性

Description

SRT 2104 is a small moleculeSirtuin 1activator.

In Vivo

The sirtuins (SIRT1-7) are a family of nicotinamide adenine dinucleotide (NAD+)-dependent deacylases with remarkable abilities to prevent diseases and even reverse aspects of ageing.SRT 2104 penetrates the blood–brain barrier, attenuates brain atrophy, improves motor function, and extends survival in a mouse model of Huntington's disease. These findings imply a novel therapeutic strategy for Huntington's disease by targeting Sirtuin 1[1]. SRT2104, a synthetic small molecule activator of SIRT1, extends both mean and maximal lifespan of mice fed a standard diet. This is accompanied by improvements in health, including enhanced motor coordination, performance, bone mineral density, and insulin sensitivity associated with higher mitochondrial content and decreased inflammation. Short-term SRT2104 treatment preserves bone and muscle mass in an experimental model of atrophy[2]. Two SRT2104 clinical trials in elderly volunteers and otherwise healthy smokers show a slight reduction in body weight, a 15-30% improvement in the cholesterol ratio and a 19% decrease in triglyceride levels129,130. A separate study of patients with the inflammatory condition plaque-type psoriasis shows a significant reduction in disease mani-festation following 84 days of oral administration of 500 or 1,000 mg per kg SRT2104[3].

References

[1].Jiang WJ. Sirtuins: novel targets for metabolic disease in drug development. Biochem Biophys Res Commun. 2008 Aug 29;373(3):341-4.