科学问题

1. 微生物多样性原因（单细胞测序，单菌的进化）
   生长繁殖快，突变速率高，分子进化水平揭示，多样化的微生物世界
   系统发育分析，MEGA
   单细胞高清照片，流氏细胞仪分选测序。把每个单细胞标注二维码，来构建数据库。

2. population的进化

3. 群落结构的驱动因素解释（群落的进化）

4. 生态系统的进化（宏基因组测序）

模拟深海环境，温度变化，环境恶化对深海生态系统的影响，预测是终极目的。

from raw metagenomic reads to ecosystem analytical capability

The ultimate goal of metagenomics is to provide a descriptive and eventually predictive metabolic and taxonomic model of an ecosystem.
Essentially, we must look toward the smallest and most ignored among us to understand our future on this planet.

The last two years have witnessed a sequencing revolution, and there
is no doubt that in the next two years, we will see a computational revolution to cope with the sequence data