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神经系统marker (Nature Neuroscience,

神经系统marker (Nature Neuroscience,

作者: 小熊_wh | 来源:发表于2022-05-10 22:37 被阅读0次

    文章:A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortex
    PMID: 30349106

    文章中针对神经元、少突胶质细胞、星形胶质细胞、小胶质细胞、内皮细胞分别给了marker,个人觉得最主要是的神经元没有区分兴奋性和抑制性神经元,直接用ENO2基因作为神经元的marker了。

    ## Nat Neurosci markers
    genelist=c('ENO2',   # neurons
               'OLIG2',  # oligodendrocytes
               'GFAP',  # astrocytes
               'CD68',  # microglia
               'CD34'   # endothelial cells)
    

    看看NCBI里面关于ENO2的描述:'This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008]'

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