circRNA与m6A

N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis

Nat Commun 2019 Oct 16;10(1)
这篇NC关于circRNA的功能研究与一般的circRNA研究并无不同，亮点在于证实了YTHDC1和IGF2BP2可以与circNSUN2结合。其中IGF2BP2可与circNSUN2结合形成circNSUN2/IGF2BP2/HMGA2 RNA-蛋白三聚体，稳定HMGA2 mRNA，从而促进结直肠癌的转移。而YTHDC1作为一种m6A reader，可以与circNSUN2的exon5−exon4 junction序列GAACU m6A motif结合，从而调控circNSUN2由核质向胞质的转移过程。

N6-Methyladenosine Modification Controls Circular RNA Immunity

Mol. Cell 2019 Oct 03;76(1)

Extensive translation of circular RNAs driven by N6-methyladenosine

Cell Res. 2017 May;27(5)