偶然发现的，这个是一个自动注释的网站（Azimuth (hubmapconsortium.org)
）。 有R包，也有网站。 网站上有他们的参考集，里面有marker。样本类型不多，就是下面这些。
image.png
下面是PBMC的marker
<summary style="box-sizing: inherit; font-size: 20px;">celltype.l1</summary> <slot id="details-content" style="color: rgb(74, 74, 74); font-family: Inter; font-size: 16px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">| Label | Expanded Label | OBO Ontology ID | Markers |
| --- | --- | --- | --- |
| Mono | Monocyte | monocyte | CTSS, FCN1, NEAT1, LYZ, PSAP, S100A9, AIF1, MNDA, SERPINA1, TYROBP |
| CD4 T | CD4+ T cell | CD4-positive, alpha-beta T cell | IL7R, MAL, LTB, CD4, LDHB, TPT1, TRAC, TMSB10, CD3D, CD3G |
| CD8 T | CD8+ T cell | CD8-positive, alpha-beta T cell | CD8B, CD8A, CD3D, TMSB10, HCST, CD3G, LINC02446, CTSW, CD3E, TRAC |
| NK | natural killer cell | natural killer cell | NKG7, KLRD1, TYROBP, GNLY, FCER1G, PRF1, CD247, KLRF1, CST7, GZMB |
| B | B cell | mature B cell | CD79A, RALGPS2, CD79B, MS4A1, BANK1, CD74, TNFRSF13C, HLA-DQA1, IGHM, MEF2C |
| other T | other T cell | mature T cell | CD3D, TRDC, GZMK, KLRB1, NKG7, TRGC2, CST7, LYAR, KLRG1, GZMA |
| DC | dendritic cell | dendritic cell | CD74, HLA-DPA1, HLA-DPB1, HLA-DQA1, CCDC88A, HLA-DRA, HLA-DMA, CST3, HLA-DQB1, HLA-DRB1 |</slot>
<summary style="box-sizing: inherit; font-size: 20px;">celltype.l2 (default)</summary> <slot id="details-content" style="color: rgb(74, 74, 74); font-family: Inter; font-size: 16px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">| Label | Expanded Label | OBO Ontology ID | Markers |
| --- | --- | --- | --- |
| B intermediate | Intermediate B cell | mature B cell | MS4A1, TNFRSF13B, IGHM, IGHD, AIM2, CD79A, LINC01857, RALGPS2, BANK1, CD79B |
| B memory | Memory B cell | memory B cell | MS4A1, COCH, AIM2, BANK1, SSPN, CD79A, TEX9, RALGPS2, TNFRSF13C, LINC01781 |
| B naive | Naive B cell | naive B cell | IGHM, IGHD, CD79A, IL4R, MS4A1, CXCR4, BTG1, TCL1A, CD79B, YBX3 |
| Plasmablast | Plasmablast | plasmablast | IGHA2, MZB1, TNFRSF17, DERL3, TXNDC5, TNFRSF13B, POU2AF1, CPNE5, HRASLS2, NT5DC2 |
| CD4 CTL | CD4+ Cytotoxic T | CD4-positive, alpha-beta cytotoxic T cell | GZMH, CD4, FGFBP2, ITGB1, GZMA, CST7, GNLY, B2M, IL32, NKG7 |
| CD4 Naive | CD4+ Naive T | naive thymus-derived CD4-positive, alpha-beta T cell | TCF7, CD4, CCR7, IL7R, FHIT, LEF1, MAL, NOSIP, LDHB, PIK3IP1 |
| CD4 Proliferating | CD4+ Proliferating T | activated CD4-positive, alpha-beta T cell | MKI67, TOP2A, PCLAF, CENPF, TYMS, NUSAP1, ASPM, PTTG1, TPX2, RRM2 |
| CD4 TCM | CD4+ Central Memory T | CD4-positive, alpha-beta memory T cell | IL7R, TMSB10, CD4, ITGB1, LTB, TRAC, AQP3, LDHB, IL32, MAL |
| CD4 TEM | CD4+ Effector Memory T | effector CD4-positive, alpha-beta T cell | IL7R, CCL5, FYB1, GZMK, IL32, GZMA, KLRB1, TRAC, LTB, AQP3 |
| Treg | Regulatory T | regulatory T cell | RTKN2, FOXP3, AC133644.2, CD4, IL2RA, TIGIT, CTLA4, FCRL3, LAIR2, IKZF2 |
| CD8 Naive | CD8+ Naive T | naive thymus-derived CD8-positive, alpha-beta T cell | CD8B, S100B, CCR7, RGS10, NOSIP, LINC02446, LEF1, CRTAM, CD8A, OXNAD1 |
| CD8 Proliferating | CD8+ Proliferating T | activated CD8-positive, alpha-beta T cell | MKI67, CD8B, TYMS, TRAC, PCLAF, CD3D, CLSPN, CD3G, TK1, RRM2 |
| CD8 TCM | CD8+ Central Memory T | CD8-positive, alpha-beta memory T cell | CD8B, ANXA1, CD8A, KRT1, LINC02446, YBX3, IL7R, TRAC, NELL2, LDHB |
| CD8 TEM | CD8+ Effector Memory T | effector CD8-positive, alpha-beta T cell | CCL5, GZMH, CD8A, TRAC, KLRD1, NKG7, GZMK, CST7, CD8B, TRGC2 |
| ASDC | AXL+ Dendritic Cell | dendritic cell | PPP1R14A, LILRA4, AXL, IL3RA, SCT, SCN9A, LGMN, DNASE1L3, CLEC4C, GAS6 |
| cDC1 | Conventional Dendritic Cell 1 | CD141-positive myeloid dendritic cell | CLEC9A, DNASE1L3, C1orf54, IDO1, CLNK, CADM1, FLT3, ENPP1, XCR1, NDRG2 |
| cDC2 | Conventional Dendritic Cell 2 | CD1c-positive myeloid dendritic cell | FCER1A, HLA-DQA1, CLEC10A, CD1C, ENHO, PLD4, GSN, SLC38A1, NDRG2, AFF3 |
| pDC | Plasmacytoid Dendritic Cell | plasmacytoid dendritic cell | ITM2C, PLD4, SERPINF1, LILRA4, IL3RA, TPM2, MZB1, SPIB, IRF4, SMPD3 |
| CD14 Mono | CD14+ Monocyte | CD14-positive, CD16-negative classical monocyte | S100A9, CTSS, S100A8, LYZ, VCAN, S100A12, IL1B, CD14, G0S2, FCN1 |
| CD16 Mono | CD16+ Monocyte | CD14-low, CD16-positive monocyte | CDKN1C, FCGR3A, PTPRC, LST1, IER5, MS4A7, RHOC, IFITM3, AIF1, HES4 |
| NK | CD56-dim Natural Killer | CD16-positive, CD56-dim natural killer cell, human | GNLY, TYROBP, NKG7, FCER1G, GZMB, TRDC, PRF1, FGFBP2, SPON2, KLRF1 |
| NK Proliferating | Proliferating Natural Killer | natural killer cell | MKI67, KLRF1, TYMS, TRDC, TOP2A, FCER1G, PCLAF, CD247, CLSPN, ASPM |
| NK_CD56bright | CD56-bright Natural Killer | CD16-negative, CD56-bright natural killer cell, human | XCL2, FCER1G, SPINK2, TRDC, KLRC1, XCL1, SPTSSB, PPP1R9A, NCAM1, TNFRSF11A |
| Eryth | Erythroid cell | erythroid lineage cell | HBD, HBM, AHSP, ALAS2, CA1, SLC4A1, IFIT1B, TRIM58, SELENBP1, TMCC2 |
| HSPC | Hematopoietic stem and progenitor cell | hematopoietic precursor cell | SPINK2, PRSS57, CYTL1, EGFL7, GATA2, CD34, SMIM24, AVP, MYB, LAPTM4B |
| ILC | Innate Lymphoid Cell | innate lymphoid cell | KIT, TRDC, TTLL10, LINC01229, SOX4, KLRB1, TNFRSF18, TNFRSF4, IL1R1, HPGDS |
| Platelet | Platelet | platelet | PPBP, PF4, NRGN, GNG11, CAVIN2, TUBB1, CLU, HIST1H2AC, RGS18, GP9 |
| dnT | Double-negative T | CD4-negative, CD8-negative, alpha-beta intraepithelial T cell | PTPN3, MIR4422HG, NUCB2, CAV1, DTHD1, GZMA, MYB, FXYD2, GZMK, AC004585.1 |
| gdT | gamma-delta T | gamma-delta T cell | TRDC, TRGC1, TRGC2, KLRC1, NKG7, TRDV2, CD7, TRGV9, KLRD1, KLRG1 |
| MAIT | Mucosal associated invariant T | mucosal invariant T cell | KLRB1, NKG7, GZMK, IL7R, SLC4A10, GZMA, CXCR6, PRSS35, RBM24, NCR3 |</slot>
<summary style="box-sizing: inherit; font-size: 20px;">celltype.l3</summary> <slot id="details-content" style="color: rgb(74, 74, 74); font-family: Inter; font-size: 16px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: rgb(255, 255, 255); text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial;">| Label | Expanded Label | OBO Ontology ID | Markers |
| --- | --- | --- | --- |
| ASDC_mDC | AXL+ myeloid dendritic cell | myeloid dendritic cell | AXL, LILRA4, SCN9A, CLEC4C, LTK, PPP1R14A, LGMN, SCT, IL3RA, GAS6 |
| ASDC_pDC | AXL+ plasmacytoid dendritic cell | plasmacytoid dendritic cell | LILRA4, CLEC4C, SCT, EPHB1, AXL, PROC, LRRC26, SCN9A, LTK, DNASE1L3 |
| B intermediate kappa | Intermediate B cell, kappa light chain | mature B cell | MS4A1, IGKC, IGHM, LINC01857, MARCKS, IGHD, TNFRSF13B, CD24, FCRL2, BANK1 |
| B intermediate lambda | Intermediate B cell, lambda light chain | mature B cell | MS4A1, IGLC2, IGHM, CD79A, IGLC3, IGHD, BANK1, TNFRSF13C, CD22, TNFRSF13B |
| B memory kappa | Memory B cell, kappa light chain | memory B cell | BANK1, IGKC, LINC01781, MS4A1, SSPN, CD79A, RALGPS2, TNFRSF13C, LINC00926 |
| B memory lambda | Memory B cell, lambda light chain | memory B cell | BANK1, IGLC2, MS4A1, IGLC3, COCH, TNFRSF13C, IGHA2, BLK, TNFRSF13B, LINC01781 |
| B naive kappa | Naive B cell, kappa light chain | naive B cell | IGHM, TCL1A, IGHD, IGHG3, CD79A, IL4R, CD37, MS4A1, IGKC |
| B naive lambda | Naive B cell, lambda light chain | naive B cell | IGHM, IGLC2, IGHD, IGLC3, CD79A, CXCR4, MS4A1, IL4R, TCL1A, CD79B |
| CD14 Mono | CD14+ Monocyte | CD14-positive, CD16-negative classical monocyte | S100A9, CTSS, LYZ, CTSD, S100A8, VCAN, CD14, FCN1, S100A12, MS4A6A |
| CD16 Mono | CD16+ Monocyte | CD14-low, CD16-positive monocyte | LST1, YBX1, AIF1, FCGR3A, NAP1L1, MS4A7, FCER1G, TCF7L2, COTL1, CDKN1C |
| CD4 CTL | CD4+ Cytotoxic T | CD4-positive, alpha-beta cytotoxic T cell | GZMH, CD4, GNLY, FGFBP2, IL7R, S100A4, GZMA, CST7, IL32, CCL5 |
| CD4 Naive | CD4+ Naive T | naive thymus-derived CD4-positive, alpha-beta T cell | TCF7, CD4, NUCB2, LDHB, TRAT1, SARAF, FHIT, LEF1, CCR7, IL7R |
| CD4 Proliferating | CD4+ Proliferating T | activated CD4-positive, alpha-beta T cell | MKI67, TYMS, PCLAF, TOP2A, CENPF, NUSAP1, CENPM, BIRC5, ZWINT, TPX2 |
| CD4 TCM_1 | CD4+ Central Memory T_1 | CD4-positive, alpha-beta memory T cell | LTB, CD4, FYB1, IL7R, LIMS1, MAL, TMSB4X, TSHZ2, AP3M2, TRAC |
| CD4 TCM_2 | CD4+ Central Memory T_2 | CD4-positive, alpha-beta memory T cell | CTLA4, MIR4435-2HG, TMSB4X, CD28, CDCA7, TMSB10, MAF, ITM2A, TRAC, CD27 |
| CD4 TCM_3 | CD4+ Central Memory T_3 | CD4-positive, alpha-beta memory T cell | IL7R, ITGB1, LTB, S100A4, AQP3, TNFRSF4, IL32, TOB1, PDE4D, HOPX |
| CD4 TEM_1 | CD4+ Effector Memory T_1 | effector CD4-positive, alpha-beta T cell | GZMK, IL7R, IL32, ITGB1, CCL5, GZMA, B2M, DUSP2, KLRB1, SYNE2 |
| CD4 TEM_2 | CD4+ Effector Memory T_2 | effector CD4-positive, alpha-beta T cell | GZMK, CD4, TIGIT, IFNG-AS1, CD40LG, MALAT1, CD3G, CD3D, TRAC, CD3E |
| CD4 TEM_3 | CD4+ Effector Memory T_3 | effector CD4-positive, alpha-beta T cell | IL7R, CCL5, NOSIP, KLRB1, SERINC5, AQP3, ITGA4, IL32, TRAC, LTB |
| CD4 TEM_4 | CD4+ Effector Memory T_4 | effector CD4-positive, alpha-beta T cell | CCR9, KDF1, DPP4, CD244, SLC4A4, KLRB1, TMIGD2, CD40LG, IL7R, ODF2L |
| CD8 Naive | CD8+ Naive T | naive thymus-derived CD8-positive, alpha-beta T cell | CD8B, LDHB, LEF1, LINC02446, CD8A, S100B, ID2, TCF7, VIM, CCR7 |
| CD8 Naive_2 | CD8+ Naive T_2 | naive thymus-derived CD8-positive, alpha-beta T cell | CD8B, CCR5, CHI3L2, SOX4, CD8A, TNFRSF9, CD38, SIRPG, LRRN3, LEF1 |
| CD8 Proliferating | CD8+ Proliferating T | activated CD8-positive, alpha-beta T cell | PCLAF, CD8B, TYMS, CD3D, CLSPN, CD3G, MKI67, TRAC, CHEK1, TK1 |
| CD8 TCM_1 | CD8+ Central Memory T_1 | CD8-positive, alpha-beta memory T cell | CD8B, SELL, CD8A, LYAR, ITGB1, NELL2, DUSP2, IL7R, CCL5, LINC01871 |
| CD8 TCM_2 | CD8+ Central Memory T_2 | CD8-positive, alpha-beta memory T cell | CD8B, C1orf162, IL7R, GATA3, YBX3, KRT1, CD8A, CTSW, INPP4B, LTB |
| CD8 TCM_3 | CD8+ Central Memory T_3 | CD8-positive, alpha-beta memory T cell | CD8B, KLRB1, CD8A, HOPX, IL7R, KLRD1, CCL5, SCML4, LINC02446, TRAC |
| CD8 TEM_1 | CD8+ Effector Memory T_1 | effector CD8-positive, alpha-beta T cell | GZMK, CD8B, CD8A, CCL5, NKG7, DUSP2, CST7, IL32 |
| CD8 TEM_2 | CD8+ Effector Memory T_2 | effector CD8-positive, alpha-beta T cell | CD8A, CMC1, CD8B, CD160, GZMH, CST7, KLRD1, CCL5, TIGIT, KLRG1 |
| CD8 TEM_3 | CD8+ Effector Memory T_3 | effector CD8-positive, alpha-beta T cell | GZMK, CD8A, ITGB1, CD8B, HOPX, CCL5, KLRD1, NKG7, GNLY, YBX3 |
| CD8 TEM_4 | CD8+ Effector Memory T_4 | effector CD8-positive, alpha-beta T cell | GZMH, THEMIS, GNLY, CD8A, ITGB1, FGFBP2, CD2, GZMB, KLRD1, CD8B |
| CD8 TEM_5 | CD8+ Effector Memory T_5 | effector CD8-positive, alpha-beta T cell | GZMH, GNLY, ZNF683, TRAC, KLRC2, TYROBP, CD8B, CD8A, TRGC2, GZMB |
| CD8 TEM_6 | CD8+ Effector Memory T_6 | effector CD8-positive, alpha-beta T cell | TRGC2, CD8A, IFNG-AS1, CD8B, ZNF683, KLRC2, NCR3, IKZF2, DUSP2, RTKN2 |
| cDC1 | Conventional Dendritic Cell 1 | CD141-positive myeloid dendritic cell | WDFY4, C1orf54, CLEC9A, BATF3, CLNK, TSPAN33, FLT3, CADM1, IDO1, DNASE1L3 |
| cDC2_1 | Conventional Dendritic Cell 2_1 | CD1c-positive myeloid dendritic cell | FCER1A, CD14, CLEC10A, CTSS, ENHO, CD1C, MRC1, FCGR2B, PID1, IL13RA1 |
| cDC2_2 | Conventional Dendritic Cell 2_2 | CD1c-positive myeloid dendritic cell | FCER1A, BASP1, CD1C, CD74, CLEC10A, HLA-DPA1, ENHO, HLA-DPB1, PLD4, HLA-DQA1 |
| dnT_1 | Double-negative T_1 | CD4-negative, CD8-negative, alpha-beta intraepithelial T cell | GZMK, NUCB2, CD8B, GPR183, TCF7, LYAR, MALAT1, C12orf57, LEF1, LDHB |
| dnT_2 | Double-negative T_2 | CD4-negative, CD8-negative, alpha-beta intraepithelial T cell | AC004585.1, GPR183, FXYD2, NUCB2, CAV1, CD27, MYB, TMSB4X, GZMK, FGFR1 |
| Eryth | Erythroid cell | erythroid lineage cell | HBM, ALAS2, HBD, AHSP, SLC4A1, TRIM58, SELENBP1, CA1, IFIT1B, SNCA |
| gdT_1 | gamma-delta T_1 | gamma-delta T cell | TRDC, TRGC1, TRGV9, TRDV2, KLRD1, IL7R, KLRC1, DUSP2, GNLY, KLRG1 |
| gdT_2 | gamma-delta T_2 | gamma-delta T cell | KLRC2, CD3G, KIR3DL2, CD3D, TRDC, TRDV1, ZNF683, KLRC1, TRGC1, GZMH |
| gdT_3 | gamma-delta T_3 | gamma-delta T cell | RTKN2, TRDC, TRGC2, LEF1, IKZF2, SOX4, ZNF331, ARID5B, NUCB2, CRTAM |
| gdT_4 | gamma-delta T_4 | gamma-delta T cell | TRDC, TIGIT, KLRC2, TRGC2, IKZF2, GCSAM, FCRL6, TRDV1, CST7, CMC1 |
| HSPC | Hematopoietic stem and progenitor cell | hematopoietic precursor cell | CDK6, SOX4, PRSS57, AC084033.3, ANKRD28, FAM30A, MYB, EGFL7, SPINK2, SMIM24 |
| ILC | Innate Lymphoid Cell | innate lymphoid cell | KIT, TRDC, IL1R1, SOX4, TNFRSF18, TYROBP, TNFRSF4, FCER1G, IL2RA, GATA3 |
| MAIT | Mucosal associated invariant T | mucosal invariant T cell | KLRB1, NKG7, GZMK, SLC4A10, NCR3, CTSW, IL7R, KLRG1, CEBPD, DUSP2 |
| NK Proliferating | Proliferating Natural Killer | natural killer cell | STMN1, KLRF1, TYMS, FCER1G, PCNA, TYROBP, CLSPN, TRDC, PCLAF, SMC2 |
| NK_1 | CD56-dim Natural Killer_1 | CD16-positive, CD56-dim natural killer cell, human | FGFBP2, KLRC2, GNLY, S100A4, CD3E, CST7, LGALS1, PRF1, NKG7, GZMB |
| NK_2 | CD56-dim Natural Killer_2 | CD16-positive, CD56-dim natural killer cell, human | NKG7, FCER1G, PRF1, KLRB1, SPON2, GZMB, FGFBP2, IGFBP7, CST7, B2M |
| NK_3 | CD56-dim Natural Killer_3 | CD16-positive, CD56-dim natural killer cell, human | KLRF1, CCL5, TRDC, SYNE2, KLRC1, CMC1, XCL2, KLRB1, KLRD1, IL2RB |
| NK_4 | CD56-dim Natural Killer_4 | CD16-positive, CD56-dim natural killer cell, human | XCL2, SELL, XCL1, GZMK, KLRC1, SPTSSB, KLRF1, IL2RB, TCF7, TRDC |
| NK_CD56bright | CD56-bright Natural Killer | CD16-negative, CD56-bright natural killer cell, human | XCL2, GPR183, SELL, IL2RB, CD44, GZMK, KLRF1, TPT1, KLRC1, XCL1 |
| pDC | Plasmacytoid Dendritic Cell | plasmacytoid dendritic cell | CCDC50, UGCG, TCF4, LILRA4, IRF8, IL3RA, PLD4, IRF7, SERPINF1, ITM2C |
| Plasma | Plasma cell | plasma cell | MZB1, JCHAIN, TNFRSF17, ITM2C, DERL3, TXNDC5, POU2AF1, IGHA1, TXNDC11, CD79A |
| Plasmablast | Plasmablast | plasmablast | TYMS, TNFRSF17, SHCBP1, TK1, KNL1, ASPM, TXNDC5, TPX2, RRM2, BIRC5 |
| Platelet | Platelet | platelet | GNG11, PPBP, NRGN, PF4, CAVIN2, TUBB1, HIST1H2AC, PRKAR2B, CLU, F13A1 |
| Treg Memory | Memory Regulatory T | regulatory T cell | RTKN2, B2M, TIGIT, FCRL3, S100A4, AC133644.2, CTLA4, FOXP3, IKZF2, TRAC |
| Treg Naive | Naive Regulatory T | regulatory T cell | RTKN2, LEF1, FOXP3, C12orf57, IL2RA, TOMM7, CCR7, TRAC, CD4, LDHB |</slot>
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