Maxacalcitol-D6

"目录号: HY-15329

Vitamin D Related-

Maxacalcitol-D6是Maxacalcitol (22-Oxacalcitriol)的氘化形式，是非血钙维生素D3类似物和VDR样受体VDR配体。

VD/VDR

相关产品

Calcitriol-Calcipotriol-Maxacalcitol-Ercalcidiol-Alfacalcidol-Calcifediol monohydrate-Paricalcitol-Seocalcitol-Secalciferol-3-O-(2-Aminoethyl)-25-hydroxyvitamin D3-Ercalcitriol-Vitamin D4-Calcitetrol-Calcitriol Impurities A-Cholecalciferol-

生物活性

Description

Maxacalcitol-D6 is the deuterated form of Maxacalcitol (22-Oxacalcitriol), which is a non-calcemic vitamin D3 analog and VDR ligand of VDR-like receptors. IC50 value:Target: Maxacalcitol (22-Oxacalcitriol)suppresses parathyroid hormone (PTH) mRNA expression in vitro and in vivo. Maxacalcitol exhibits similar effects to calcitriol in osteoblast-like cells. Maxacalcitol(22-Oxacalcitriol) inhibits tumor growth of osteosarcoma in vitro in combination with all-trans retinoic acid.

References

[1].Monier-Faugere et al  22-Oxacalcitriol suppresses secondary hyperparathyroidism without inducing low bone turnover in dogs with renal failure. Kidney Int. (1999)55 821.

[2].Barroga et al  Inhibitory effects of 22-oxa-calcitriol and all-trans retinoic acid on the growth of a canine osteosarcoma derived cell-line in vivo and its pulmonary metastasis in vivo. Res.Vet.Sci. (2000)68 79.

[3].Inoue K, Matsui I, Hamano T, Fujii N, Shimomura A, Nakano C, Kusunoki Y, Takabatake Y, Hirata M, Nishiyama A, Tsubakihara Y, Isaka Y, Rakugi H.Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex to pS

[4].Karashima T, Hashikawa K, Ono F, Eguchi H, Hamada T, Ishii N, Dainichi T, Yasumoto S, Tsuruta D, Hashimoto T.Successful Treatment of Bowen's Disease with Topical Maxacalcitol.Acta Derm Venereol. 2012 Jan 26.