抗体

1. VEGF 和IL-6的抗体购买：

VEGF VEGFA和MDSC的密切关系

文献（1）：Inhibition of JAK2/STAT3 reduces tumor‐induced angiogenesis and myeloid‐derived suppressor cells in head and neck cancer。
Results showed that inhibition of JAK2/STAT3 suppressed angiogenesis by decreasing VEGFA and HIF1-α both in vitro and vivo.
表明了VEGFA和MDSC的细胞的关系密切
文献（2）：CXCL1 Is Critical for Premetastatic Niche Formation and Metastasis in Colorectal Cancer。
Here, we demonstrate that colorectal carcinoma cells secrete VEGFA, which stimulates tumor-associated macrophages to produce CXCL1 in the primary tumor. Elevation of CXCL1 in premetastatic liver tissue recruited CXCR2-positive myeloid-derived suppressor cells (MDSC) to form a premetastatic niche that ultimately promoted liver metastases.
再次证明VEGFA和MDSC关系密切。

IL-6 IL-6和PI3K/Akt通路的关系

文献（1）PI3Kδ Inhibition as a Potential Therapeutic Target in COVID-19。
The interesting and evolving potential of phosphoinositide 3-kinase δ (PI3Kδ) inhibitors, together with Ebastine, lies in their ability to suppress the release of pro-inflammatory cytokines, such as IL-1β, IL-8, IL-6, and TNF-α, by T cells.
文献（2） SHIP prevents lipopolysaccharide from triggering an antiviral response in mice。
Intriguingly, we found, using isoform-specific PI3K inhibitors, that LPS- or cytosine-phosphate-guanosine-induced interleukin-6 (IL-6) is positively regulated by p110alpha, -gamma, and -delta but negatively regulated by p110beta.

VEGF 和PI3K/Akt通路的关系

文献（1）Copanlisib, a novel phosphoinositide 3-kinase inhibitor, combined with carfilzomib inhibits multiple myeloma cell proliferation。
Copanlisib, also known as BAY80-6946, is a potent PI3Kα and δ inhibitor. Further, copanlisib inhibited vascular endothelial growth factor (VEGF)-mediated angiogenesis in vitro and in vivo.
文献（2）These beneficial effects were associated with upregulation of the PI3K/Akt/HIF1α signaling pathway, and increased expression of its downstream targets-GLUT-4 and VEGF-A.
Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications
文献（3）XQ-1H promotes cerebral angiogenesis via activating PI3K/Akt/GSK3β/β-catenin/VEGF signal in mice exposed to cerebral ischemic injury.
Mechanism studies revealed that XQ-1H exerted angiogenesis promoting effect via the PI3K/Akt/GSK3β/β-catenin/VEGF signal pathway, which was reversed by LY294002 (the specific inhibitor of PI3K/Akt)

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