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基质细胞类型的注释总结

基质细胞类型的注释总结

作者: Seurat_Satija | 来源:发表于2021-09-04 11:11 被阅读0次
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    成纤维细胞:

    The first CAF sub-cluster was comprised of 280 cells (16.2% of all stromal; red cluster) and was classified as myofibroblast-like CAFs (myCAFs) through the elevated expression of activated fibroblast markers (ACTA2, FAP and PDPN) and collagen-related genes (COL1A1 and COL1A2);

    Fibroblast 注释成两类:周皮细胞,平滑肌细胞和成纤维细胞
    myofibroblast-like CAFs : ACTA2, FAP, PDPN;
    inflammatory-CAFs (iCAFs):CXCL12;
    differentiated-PVL(dPVAL): TAGLN, MYH11,MYLK;
    immature-PVL (imPVL): PDGFRB, CD36, RGS5;

    内皮细胞:

    endothelial cells provide nutrients for tumour growth, constitute routes for metastatic dissemination through angiogenesis, and contribute to resistance to ‘chemotherapies and radiation’.

    内皮细胞:(PECAM1,VWF, ENG)We identified five subtypes of endothelial cells (EC) including lymphatic, venous, and arterial endothelial cells (LEC, VECs, and AECs), tip cells, and an EC cluster enriched with interferon induced genes

    淋巴内皮细胞(LEC):PDPN, PROX1;
    静脉内皮细胞(VEC): ACKR1;
    动脉内皮细胞(AEC): GJA5;
    顶端细胞(tip cell):KCNE3,ESM1,ANGPT2,APLN;
    干扰素EC细胞:干扰素相关基因。

    作者:麻花拧巴
    链接:https://www.jianshu.com/p/5efd228b9b76

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