摘要

Embryonic pluripotency can be recapitulated in vitro by a spectrum of pluripotent stem cell states stabilized with different culture conditions. Their distinct spatiotemporal characteristics provide an unprecedented tool for the study of early human development. The newly unveiled ability of some stem cell types for crossing xeno-barriers will facilitate the generation of interspecies chimeric embryos from distant species, including humans. When combined with efficient zygote genome editing technologies, xenogeneic human pluripotent stem cells may also open new frontiers for regenerative medicine applications, including the possibility of generating human organs in animals via interspecies chimeric complementation.
胚胎多能性可以在体外通过一系列用不同培养条件稳定的多能干细胞状态来概括。它们独特的时空特征为研究早期人类发展提供了前所未有的工具。一些干细胞类型新发现的跨越异种屏障的能力将促进从包括人类在内的遥远物种中产生种间嵌合胚胎。当与有效的受精卵基因组编辑技术相结合时，异种人类多能干细胞也可能为再生医学应用开辟新的领域，包括通过种间嵌合互补在动物体内产生人体器官的可能性。