羟基和羧基是亲水性基团,所以胆汁酸的亲水性依赖于羟基的数目
一个羟基的胆汁酸:LCA(最疏水的胆汁酸)0.00005
两个个羟基的胆汁酸:DCA(高度不溶,结肠癌的促进因子)1.5,UDCA(高度可溶、无毒,91),CDCA(疏水,10)
三个个羟基的胆汁酸:CA(640),α-MCA/β-MCA/w-MCA(高度可溶、无毒)
疏水性胆汁酸:DCA/CDCA/LCA/TDCA/TCDCA
亲水性胆汁酸:UDCA/TUDCA/THDCA/a-MCA/b-/CA/TCA
疏水性胆汁酸更容易排出吗?
粪便中游离胆汁酸更多吗?
参考文献:
Bile Acids as Metabolic Regulators and Nutrient Sensors - PubMed (nih.gov)
Solubility of calcium salts of unconjugated and conjugated natural bile acids - PubMed (nih.gov)
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