Adhension of Double Network Gel

Adhension of Double Network Gel 双网凝胶的粘合

Most parts of the living body are made of gels, except for hard tissues such as teeth or bones. DN hydrogels are considered as attractive candidates for the fabrication of artificial cartilages because of their extremely high mechanical strength (fracture stress = 170 kg/cm2) and low friction. DN gels used in artificial cartilages must bond strongly with hydroxyapatite found in artificial bone; hence, it is necessary to fix the gels firmly onto a solid substrate.
除了牙齿或骨头等硬组织外，生物体的大多数部分都是由凝胶制成的。DN水凝胶被认为是制造人造软骨的有吸引力的候选者，因为它们具有极高的机械强度（断裂应力= 170kg / cm2）和低摩擦。人造软骨中使用的DN凝胶必须与人造骨中的羟基磷灰石强烈结合; 因此，必须将凝胶牢固地固定在固体基质上。

We attempted to bond DN gels with porous solid substrates through a gradient structure.
我们试图通过梯度结构将DN凝胶与多孔固体基质结合。

• First, poly(2-acrylamido-2-methylpropanesulfonic acid) (PAMPS) gel, which is used to form the first network, is synthesized in voids in the porous solid substrate.首先，用于形成第一网络的聚（2-丙烯酰胺基-2-甲基丙磺酸）（PAMPS）凝胶在多孔固体基质中的空隙中合成。
• Then, the porous solid substrate containing PAMPS gel is immersed in a solution of acrylamide (AAm) , which is used to form the second network. Subsequently, the porous solid is brought in contact with a portion of the PAMPS gel sheet, which is also soaked in the AAm solution.然后，将含有PAMPS凝胶的多孔固体基质浸入丙烯酰胺（AAm）溶液中，用于形成第二网络。随后，使多孔固体与PAMPS凝胶片的一部分接触，其也浸泡在AAm溶液中。
• Thus, the poly(acrylamide) (PAAm) gel is simultaneously synthesized in both the porous solid substrate and in the PAMPS sheet.因此，在多孔固体基质和PAMPS片材中同时合成聚（丙烯酰胺）（PAAm）凝胶。

This method results in a DN structure both in the porous solid substrate and in the gel sheet.
该方法在多孔固体基质和凝胶片中都产生DN结构。

A strong interface between tough PAMPS/PAAm DN gels and various porous solid substrates is achieved via DN formation. It is found that the strength of the gel-substrate interface depends on the pore size of the solid substrates. Porous solids, with pore sizes in the order of several micrometers, result in the formation of strong gel-substrate interfaces. Under optimal conditions, the bonding strength between the gel and the substrate is comparable to the bonding strength of the bulk DN gel.
通过DN形成实现了坚韧的PAMPS / PAAm DN凝胶与各种多孔固体基质之间的强界面。发现凝胶 - 基底界面的强度取决于固体基质的孔径。孔径为几微米的多孔固体导致形成强的凝胶 - 基底界面。在最佳条件下，凝胶和基材之间的粘合强度与块状DN凝胶的粘合强度相当。