Treg相关

作者: Yayamia | 来源:发表于2023-03-26 21:44 被阅读0次

分类一:nTreg和iTreg

参考: https://www.sohu.com/a/247099502_610701

  • There are two major regulatory T-cell subsets, "natural" CD4(+) Treg (nTreg) cells that develop in the thymus and "induced" Treg (iTreg) cells that develop from conventional CD4(+) T (Tconv) cells in the periphery.
  • It has been indicated by various experiments that a developing T cell with an intermediate affinity TCR for a self-peptide/MHC is driven to the Treg cell lineage, while a T cell with a high-affinity TCR for the ligand is deleted, and one with a low-affinity TCR differentiates into a naive T cell

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