【铁死亡>>预后模型】06.铁死亡+colon cancer (

PMID: 33926457
发表杂志：World Journal of Surgical Oncology

本文因为缺少验证，因此影响因子并不高，其实作者加上内部验证或外部验证，应该会提高1-2分。

Fig.9

The pattern diagram of ferroptosis-related genes in colon cancer. Erastin deprives cellular cysteine, leading to GSH deletion and GPX4 inactivation. GSH is inhibited by cysteinyl-tRNA synthetase (CARS), leading to GPX4 inactivation. TPAP2C promotes the expression of GPX4 inactivation that leads to the generation of reactive oxygen species (ROS) and accumulation of lipid peroxides and final ferroptosis. NOX4, CKDN2A, and the decrease of GLUT3 and DRD4 result in accumulation of ROS, leading to ferroptosis. The mechanism of how WIPI1 regulates ferroptosis is unclear

知识点

• Ferroptosis-related genes, 铁死亡相关基因，作者从FerrDb数据库收集259种铁死亡相关的基因。

摘要

作者收集了FerrDb数据库的259种铁死亡相关基因→差异分析→unicox+Lasso→构建模型→GO+KEGG→单因素&多因素独立预后分析→临床特征分析→Nomgram

整体思路

结果

1.差异分析+预后分析

Fig.1

2.模型构建

Fig.2

3.富集分析

Fig.3

3.模型周边

3.1 模型与临床特征

Fig.4
Fig.6

3.2 单因素&多因素独立预后分析

Fig.5

3.3 Nomgram

Fig.7-8

亮点

• 模型构建后，PCA和t-SNE分析
• Nomgram和DCA

参考链接：
Identification of a ferroptosis-related gene signature predictive model in colon cancer