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基因组坐标 “0-base” 和 “1-base”

基因组坐标 “0-base” 和 “1-base”

作者: 热衷组培的二货潜 | 来源:发表于2019-07-01 00:39 被阅读64次
“1-start, fully-closed” = coordinates positioned within the web-based UCSC Genome Browser. 
“0-start, half-open” = coordinates stored in database tables.

Table 1. UCSC Genome Browser coordinate systems summary

0-start, half-open (0-based) 1-start, fully-closed (1-based)
“BED” format (Browser Extensible Data): “Position” format:
chr1 127140000 127140001 chr1:127140001-127140001
Note: Spaces, not punctuation note: Punctuation used, no spaces
When using BED format, brows er & utilities When using “position” format, browser & utilities
assume coords are 0-start, half-open. assume coords are 1-start, fully-closed.
Stored in UCSC Genome Browser tables Positioned in UCSC Genome Browser web interface
To convert to 1-start, fully-closed: To convert to 0-start, half-open:
add 1 to start, end = same subtract 1 from start, end = same

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