文献精读

https://doi.org/10.1126/science.adf3208

10.15252/msb.20209596

doi: 10.1002/wrna.1325

The limitation of ribosomal biogenesis will extend the lifespan and healthspan.

https://journals.biologists.com/jcs/article/128/15/2938/55119/Mitf-is-a-master-regulator-of-the-v-ATPase-forming

https://doi.org/10.1126/science.adg0934

• 1. Ribosomal subunits proteins decrease along aging
• 2. Cell type specific aging/features
• 3. Aging is different between sexes (sexual dimorphism)
• 4. Within the same tissues, cell composition change along aging
• 5. Within the same tissues, different cell types contribute differently to the aging of this tissue
• 6. The nucleus number of fat-body cells increase along aging, fay-body of Drosophila is a liver-like tissue which is account for storing fat and
     serves as a detoxifying and immune-responsive tissue