原癌基因

ABI1
ABL1
ABL2
ACSL3
ACSL6
AFF1
AFF3
AFF4
AKAP9
AKT1
AKT2
ALK
AR
ARHGAP26
ARHGEF12
ARNT
ASPSCR1
ATF1
ATIC
BCL10
BCL11A
BCL11B
BCL2
BCL3
BCL5
BCL6
BCL7A
BCL9
BCR
BIRC3
BRAF
BRD3
BRD4
BTG1
C12orf9
C15orf55
CANT1
CARD11
CARS
CASC5
CBFA2T3
CBFB
CBL
CCDC6
CCNB1IP1
CCND1
CCND2
CCND3
CD74
CD79A
CD79B
CDH11
CDK4
CDK6
CDX2
CEBPA
CHCHD7
CHIC2
CHN1
CIC
CIITA
CLP1
CLTC
CLTCL1
CNBP
CNTRL
COL1A1
COX6C
CREB1
CREB3L2
CREBBP
CRLF2
CRTC1
CRTC3
CSF1R
CTNNB1
CXCR7
DDIT3
DDX10
DDX5
DDX6
DEK
DNMT1
DNMT3A
EGFR
EIF4A2
ELF4
ELK4
ELL
ELN
EML4
EPS15
ERBB2
ERC1
ERG
ETV1
ETV4
ETV5
ETV6
EWSR1
EZH2
FCGR2B
FCRL4
FEV
FGFR1
FGFR1OP
FGFR2
FGFR3
FIP1L1
FLI1
FLT3
FNBP1
FOXL2
FOXO1
FOXO3
FOXO4
FOXP1
FSTL3
FUS
GAS7
GATA1
GATA2
GMPS
GNA11
GNAQ
GNAS
GOLGA5
GOPC
GPHN
H3F3A
HERPUD1
HIP1
HIST1H3B
HIST1H4I
HLF
HMGA1
HMGA2
HMGN2P46
HNRNPA2B1
HOOK3
HOXA11
HOXA13
HOXA9
HOXC11
HOXC13
HOXD11
HOXD13
HRAS
HSP90AA1
HSP90AB1
IDH1
IDH2
IGH
IGK
IGL
IKZF1
IL2
IL21R
IL6ST
IRF4
ITK
JAK1
JAK2
JAK3
JAZF1
JUN
KDM5A
KDR
KDSR
KIAA1549
KIT
KLF4
KLK2
KRAS
KTN1
LASP1
LCK
LCP1
LHFP
LIFR
LMO1
LMO2
LPP
LYL1
MAF
MAFB
MALAT1
MALT1
MAML2
MAP2K1
MAP2K2
MDM2
MDM4
MDS2
MECOM
MED12
MET
MITF
MKL1
MLF1
MLL
MLLT1
MLLT10
MLLT11
MLLT3
MLLT4
MLLT6
MN1
MNX1
MPL
MSI2
MSN
MTCP1
MUC1
MYB
MYC
MYCL1
MYCN
MYD88
MYH11
MYH9
NACA
NCKIPSD
NCOA1
NCOA2
NCOA3
NCOA4
NFE2L2
NFIB
NFKB2
NIN
NKX2-1
NONO
NOTCH1
NOTCH2
NPM1
NR4A3
NRAS
NSD1
NTRK1
NTRK3
NUMA1
NUP214
NUP98
OLIG2
OMD
P2RY8
PAFAH1B2
PATZ1
PAX3
PAX5
PAX7
PAX8
PBX1
PCM1
PCSK7
PDE4DIP
PDGFB
PDGFRA
PDGFRB
PER1
PICALM
PIK3CA
PIM1
PLAG1
PML
POU2AF1
POU5F1
PPARG
PPP2R1A
PRCC
PRDM16
PRRX1
PSIP1
PTPN11
RABEP1
RAF1
RANBP17
RAP1GDS1
RARA
RBM15
REL
RET
RHOH
RNF213
ROS1
RPL22
RPN1
RUNX1
RUNX1T1
SEPT5
SEPT6
SEPT9
SET
SETBP1
SF3B1
SFPQ
SH3GL1
SKP2
SLC45A3
SMO
SPECC1
SPOP
SRGAP3
SRSF2
SRSF3
SS18
SS18L1
SSX1
SSX2
SSX4
STAT3
STIL
STL
SUZ12
SYK
TAF15
TAL1
TAL2
TCEA1
TCF12
TCF3
TCL1A
TCL6
TERT
TET1
TFE3
TFEB
TFG
TFPT
TFRC
THRAP3
TLX1
TLX3
TMPRSS2
TNFRSF17
TOP1
TPM3
TPM4
TPR
TRA
TRB
TRD
TRIM24
TRIM27
TRIM33
TRIP11
TSHR
TTL
U2AF1
USP6
WHSC1
WHSC1L1
ZBTB16
ZMYM2
ZNF331
ZNF384
ZNF521

抑癌基因

ACVR1B
APC
ARID1A
ARID1B
ARID2
ASXL1
ATM
ATR
ATRX
AXIN1
B2M
BAP1
BARD1
BCOR
BLM
BMPR1A
BRCA1
BRCA2
BRIP1
BUB1B
CASP8
CBLB
CBLC
CDC73
CDH1
CDKN2A
CDKN2C
CHEK2
CYLD
DAXX
DDB2
DICER1
EP300
ERCC1
ERCC2
ERCC3
ERCC4
ERCC5
EXT1
EXT2
FAM123B
FANCA
FANCC
FANCD2
FANCE
FANCF
FANCG
FANCI
FANCL
FANCM
FAS
FBXW7
FH
FUBP1
GATA3
HNF1A
KDM5C
KDM6A
KLF6
MAP2K4
MAP3K1
MAX
MEN1
MLH1
MLL2
MLL3
MSH2
MSH6
MUTYH
NBN
NCOR1
NF1
NF2
PALB2
PBRM1
PHF6
PHOX2B
PIK3R1
PMS1
PMS2
POLD1
POLE
POLH
PRDM1
PRF1
PTCH1
PTEN
RAD50
RAD51
RAD51C
RAD51D
RAD54L
RB1
RECQL4
RNF43
SBDS
SDHAF2
SDHB
SDHC
SDHD
SETD2
SMAD2
SMAD4
SMARCA4
SMARCB1
SOCS1
SOX9
STAG2
STK11
SUFU
TET2
TNFAIP3
TP53
TRAF7
TSC1
TSC2
VHL
WRN
WT1
XPA
XPC

The TSGs list and oncogenes list were compiled as described in Huang et al., 2018. There were 3 gene sources:

image.png

10 genes (CEBPA, CIC, CREBBP, GATA1, IKZF1, NOTCH1, NOTCH2, NPM1, PAX5, RUNX1) had contradictory classifications in the GSEA database and in Vogelstein et al. 2013. These genes were all classified as TSGs from Vogelstein et al., 2013, while they were all classified as oncogenes in the GSEA database. We kept these genes as oncogenes as the GSEA database.

References

Huang KL, Mashl RJ, Wu Y, Ritter DI, Wang J, Oh C, Paczkowska M, Reynolds S, Wyczalkowski MA, Oak N, et al: Pathogenic Germline Variants in 10,389 Adult Cancers.Cell 2018, 173:355-370.

Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA, Jr., Kinzler KW: Cancer genome landscapes.Science 2013, 339:1546-1558.

Rahman N: Realizing the promise of cancer predisposition genes.Nature 2014, 505:302-308.

Zhang J, Walsh MF, Wu G, Edmonson MN, Gruber TA, Easton J, Hedges D, Ma X, Zhou X, Yergeau DA, et al: Germline Mutations in Predisposition Genes in Pediatric Cancer.N Engl J Med 2015,373:2336-2346.

The TSGs list and oncogenes list were compiled as described in Huang et al., 2018. There were 3 gene sources: