期刊
Trends in Genetics (11.821/Q1)
Simple sequence repeats as advantageous mutators in evolution (2006)
简单序列重复作为进化中的有利突变体
Simple sequence repeats (SSRs) often serve to modify genes with which they are associated. The influence of SSRs on gene regulation, transcription and protein function typically depends on the number of repeats, while mutations that add or subtract repeat units are both frequent and reversible. SSRs thus provide a prolific source of quantitative and qualitative variation. Over the past decade, researchers have found that this spontaneous variation has been tapped by natural and artificial selection to adjust almost every aspect of gene function. These studies support the hypothesis that SSRs, by virtue of their special mutational and functional qualities, have a major role in generating the genetic variation underlying adaptive evolution.
简单序列重复 (SSR) 通常用于修饰与其相关的基因。SSR 对基因调控、转录和蛋白质功能的影响通常取决于重复次数，而增加或减少重复单元的突变既频繁又可逆。因此，SSR 提供了数量和质量变化的丰富来源。在过去的十年中，研究人员发现，这种自发变异已被自然和人工选择所利用，以调整基因功能的几乎每个方面。这些研究支持了这样的假设，即 SSR 凭借其特殊的突变和功能特性，在产生适应进化的遗传变异方面具有重要作用。
文章被锁定，具体查看公众号推文。。。
网友评论